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Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration The Joslin 50-Year Medalist Study PDF Stampa E-mail
Martedì 22 Maggio 2012 06:49

OBJECTIVE To assess complication prevalence and identify protective factors in patients with diabetes duration of ≥50 years. Characterization of a complication-free subgroup in this cohort would suggest that some individuals are protected from diabetes complications and allow identification of endogenous protective factors.

RESEARCH DESIGN AND METHODS Cross-sectional, observational study of 351 U.S. residents who have survived with type 1 diabetes for ≥50 years (Medalists). Retinopathy, nephropathy, neuropathy, and cardiovascular disease were assessed in relation to HbA1c, lipids, and advanced glycation end products (AGEs). Retrospective chart review provided longitudinal ophthalmic data for a subgroup.

RESULTS A high proportion of Medalists remain free from proliferative diabetic retinopathy (PDR) (42.6%), nephropathy (86.9%), neuropathy (39.4%), or cardiovascular disease (51.5%). Current and longitudinal (the past 15 years) glycemic control were unrelated to complications. Subjects with high plasma carboxyethyl-lysine and pentosidine were 7.2-fold more likely to have any complication. Of Medalists without PDR, 96% with no retinopathy progression over the first 17 years of follow-up did not experience retinopathy worsening thereafter.

CONCLUSIONS The Medalist population is likely enriched for protective factors against complications. These factors might prove useful to the general population with diabetes if they can be used to induce protection against long-term complications. Specific AGE combinations were strongly associated with complications, indicating a link between AGE formation or processing with development of diabetic vasculopathy.

Footnotes

  • This article contains Supplementary Data online athttp://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc10-1675/-/DC1.

     

     

     

    1. Jennifer K. Sun, MD, MPH1,2,3,
    2. Hillary A. Keenan, PHD3,4,
    3. Jerry D. Cavallerano, OD, PHD1,2,
    4. Bela F. Asztalos, PHD5,
    5. Ernst J. Schaefer, MD5,
    6. David R. Sell, PHD6,
    7. Christopher M. Strauch, BSC6,
    8. Vincent M. Monnier, MD6,
    9. Alessandro Doria, MD, PHD, MPH3,
    10. Lloyd Paul Aiello, MD, PHD1,2,3 and
    11. George L. King, MD3,4

    -Author Affiliations

    1. 1Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts
    2. 2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
    3. 3Research Division, Joslin Diabetes Center, Boston, Massachusetts
    4. 4Department of Internal Medicine, Harvard Medical School, Boston, Massachusetts
    5. 5Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
    6. 6Departments of Pathology and Biochemistry, Case Western Reserve University, Cleveland, Ohio
    1. Corresponding author: George L. King,  Questo indirizzo e-mail è protetto dallo spam bot. Abilita Javascript per vederlo. .

     

     

    Fonte: Diabetes Care